Brothers by blood. Sisters by name. Here is the first official trailer for dark comedy The Sisters Brothers. The film, written and directed by Jacques Audiard, stars Joaquin Phoenix, John C. Reilly, Jake Gyllenhaal, and Riz Ahmed; and will be released in theaters in Fall 2018.

Based on Patrick Dewitt’s acclaimed novel of the same name, follows two brothers – Eli and Charlie Sisters – who are hired to kill a prospector who has stolen from their boss. The story, a genre-hybrid with comedic elements, takes place in Oregon in 1851. The film is Jacques Audiard’s follow-up to his Palme D’Or Winning DHEEPAN, which premiered at the 2015 Cannes Film Festival.